1300 - 1400 Proto-Renaissance 
1305 - Giotto completes his work on the Scrovegni Chapel in Padua. 
1308 - Dante writes his epic poem the Divine Comedy. 
1341 - The first great humanist, Petrarch, is named the poet laureate of Rome. 
1400 - 1500 Early Renaissance 
1419 - Architect Brunelleschi designs the dome for the Florence Cathedral. 
1434 - The Medici family becomes the head of the city-state of Florence. 
1450 - Johannes Gutenberg invents the printing press. 
1453 - The Ottoman Empire captures the city of Constantinople, signaling an end to the Byzantine Empire. 
1469 - Lorenzo de Medici becomes head of the city-state of Florence. He is one of the great patrons of the arts. 
1485 - Henry VII becomes king of England beginning the reign of the House of Tudor. 
1486 - Boticelli completes the painting The Birth of Venus. 
1492 - Explorer Christopher Columbus discovers the Americas. 
1495 - 1527 High Renaissance 
1495 - Leonardo da Vinci paints the Last Supper. 
1498 - Vasco da Gama arrives in India after sailing around the southern tip of Africa from Portugal. 
1501 - Michelangelo begins his work on the sculpture David. 
1503 - Leonardo da Vinci paints the Mona Lisa. 
1508 - Michelangelo begins his painting on the ceiling of the Sistine Chapel. 
1509 - Henry VIII becomes king of England. 
1509 - Humanist author Erasmus writes Praise of Folly. 
1511- Raphael paints his masterpiece The School of Athens. 
1516 - Sir Thomas More publishes his work Utopia on political philosophy. 
1517 - Martin Luther posts his 95 theses on the door of the Church of Wittenberg. This signals the start of theReformation. 
1519 - Ferdinand Magellan begins his voyage around the world. 
1527-1600 Mannerism 
1527 - Rome is sacked by the troops of Holy Roman Emperor Charles V. 
1534 - Henry VIII separates the Church of England from the Catholic Church of Rome so that he can divorce Catherine of Aragon and marry Anne Boleyn. 
1558 - Elizabeth I becomes Queen of England. 
1588 - The Spanish Armada is defeated by the English navy. 
1599 - William Shakespeare builds the Globe theatre. He will write many of his great plays over the next few years including Hamlet and Macbeth. 
1610 - Galileo discovers the moons of Jupiter. 
1618 - The Thirty Years War begins. 
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